ImmunologybioRxiv
Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Immunity
J. P. Murad, D. Tilakawardane, A. K. Park…·S. J. Priceman
This study shows that cyclophosphamide pre-conditioning improves CAR T cell efficacy against solid tumors by modifying the immunosuppressive tumor microenvironment without harming normal tissues.
DOI 10.1016/j.ymthe.2021.02.024