PhysiologybioRxivPreprint
Vasodilators activate TMEM16A channels in endothelial cells to reduce blood pressure
A. Mata-Daboin, T. A. C. Garrud, C. Fernandez-Pena…·J. H. Jaggar
Vasodilators stimulate TRPV4 channels, leading to calcium-dependent activation of nearby TMEM16A channels in endothelial cells to produce arterial hyperpolarization, vasodilation, and reduced blood pressure.
DOI 10.1101/2023.06.02.543450