Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast
S. Chalivendra, S. Shi, x. Li, Z. Kuang, J. Giovinazzo, L. Zhang, J. Rossi, A. Saviola, J. Wang, R. Welty, S. Liu, K. Vaeth, H. Zhou, K. Hansen, M. Taliaferro, R. zhao
The paper humanizes yeast U1 snRNP components to study 5 ss recognition, finding that U1C ZnF substitution causes splicing defects and mitochondrial dysfunction.
RNA · Apr 30, 2024Peer-reviewedBiochemistry