R. Prekeris

TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells

This study identifies TTLL12 as a novel microtubule regulator required for primary ciliary axoneme formation in polarized epithelial cells.

HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells

The paper shows that HOPS-dependent lysosomal fusion is necessary for Rab19 availability at the basal body, which is critical for apical actin clearing and ciliogenesis in polarized epithelial cells.

The Novel Role of Midbody-Associated mRNAs in Regulating Abscission

This study identifies MB-associated mRNAs that are locally translated to regulate abscission, showing that CHMP4B mRNA targeting to the midbody is essential for cytokinesis.

Rab40c Regulates Focal Adhesions and Protein Phosphatase 6 Activity by Controlling ANKRD28 Ubiquitylation and Degradation

This study identifies Rab40c's role in regulating focal adhesions by controlling ANKRD28 ubiquitylation and degradation, affecting PP6 activity and downstream signaling.

Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration

This study shows that Rab40b/Cul5 ubiquitylates Rap2, regulating its localization and activity during breast cancer cell migration.

Trisomy 21 induces pericentrosomal crowding disrupting early stages of primary ciliogenesis and mouse cerebellar development

This study shows that trisomy 21 causes pericentrosomal crowding, disrupting ciliogenesis and leading to neurological deficits in mice.

Trisomy 21 increases microtubules and disrupts centriolar satellite localization

This study shows that increased Pericentrin in trisomy 21 disrupts microtubule networks and mislocalizes centriolar satellites, impairing primary cilia formation.

Rab40/Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration and invasion

This study identifies Rab40b/Cullin5 complex as a regulator of EPLIN and actin cytoskeleton dynamics, affecting cell migration and invasion through focal adhesion and stress fiber changes.

The Rab11 effectors Fip5 and Fip1 regulate zebrafish intestinal development

This study shows that Fip5 and Fip1, Rab11 effectors, are critical for apical microvilli formation in zebrafish intestines, with Fip5 loss leading to microvillus inclusion disease-like phenotypes.

Rab14/MACF2/CAMSAP3 Complex Regulates Endosomal Targeting to the Abscission Site During Cytokinesis

This study identifies Rab14 as a regulator of abscission by facilitating Rab11-endosome targeting to the central spindle during cytokinesis.

CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division