K. Valdez

This study compares kidney function and injury biomarkers in rats treated with vancomycin, piperacillin-tazobactam, or both, finding no additive nephrotoxicity with the combination.

This study examines the effects of vancomycin loading doses and dose escalation on glomerular function and kidney injury biomarkers in a rat model, finding that higher doses correlate with greater kidney injury.

This study identifies hippocampal cefepime concentrations as a threshold for neurotoxicity in rats, linking plasma exposure to seizure onset.

This study compares glomerular function and urinary biomarkers in rats treated with vancomycin alone versus vancomycin plus piperacillin-tazobactam, finding no worsening of kidney function with the combination.