BioengineeringbioRxivPreprint
Computationally-guided tuning of ligand sensitivity in a GPCR-based sensor
D. Keri, R. B. Cola, K. Zacharoula…·P. Barth
The paper enhances the sensitivity of a GPCR-based dopamine sensor using computational design, achieving up to 15-fold increased potency for norepinephrine.
DOI 10.1101/2021.09.21.461282