P. Barth

Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks

This paper designs novel membrane receptors with enhanced activity and stability through engineered allosteric networks involving solvent-mediated interactions.

Computationally designed GPCR quaternary structures bias signaling pathway activation

The paper designs GPCR quaternary structures to bias signaling pathway activation and identifies a conformational switch controlling G protein vs β-arrestin recruitment.

Computationally-guided tuning of ligand sensitivity in a GPCR-based sensor

The paper enhances the sensitivity of a GPCR-based dopamine sensor using computational design, achieving up to 15-fold increased potency for norepinephrine.

Isolation and characterization of barley (Hordeum vulgare) extracellular vesicles and their role in RNAi-based crop protection

This study isolates and characterizes barley extracellular vesicles and shows they contain siRNAs but play a minor role in spray-induced gene silencing compared to HIGS.

Host-induced gene silencing involves Arabidopsis ESCRT-III pathway for the transfer of dsRNA-derived siRNA

This study identifies the Arabidopsis ESCRT-III pathway as essential for transferring dsRNA-derived siRNAs between host and fungal cells during host-induced gene silencing.