Cancer BiologybioRxiv
Cancer cell-autonomous cGAS-STING response confers drug resistance
Q.-M. Lv, S.-Y. Wang, H.-M. Lei…·L. Zhu
This study shows that cGAS-STING signaling in cancer cells promotes drug resistance by responding to cytosolic DNA from chemotherapy, suggesting caution in combining STING agonists with chemotherapy.
DOI 10.1016/j.chembiol.2023.05.005