Karen Schindler

This study shows that declining ribosome function contributes to oocyte aging by reducing translational capacity and causing developmental defects.

This study quantifies age-related changes in the mechanical properties of mouse oocyte spindles using a combination of coarse-grained modeling and in situ experiments.

This study shows that SIRT7 maintains genome stability in aging mouse testes by regulating H3K36ac, preventing premature loss of spermatogonia and meiotic defects.

The paper identifies a developmentally programmed nuclear pore complex (NPC) turnover pathway during oocyte specification in Drosophila, showing that NPC renewal is essential for proper oocyte identity and maternal provisioning.

The paper shows maternal CENP-C restores centromere symmetry in zygotes by asymmetrically recruiting to paternal centromeres, ensuring proper chromosome segregation.

The paper shows that in Mos-deficient eggs, polar bodies can re-enter the cell cycle and divide, leading to tumor formation due to disrupted MOS/MAPK signaling.

This study identifies AURKA's role in oocyte meiosis by phosphorylating HEC1 at Serine 69, which regulates SAC activation and chromosome alignment.

This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.

The study identifies genetic determinants of reproductive aging linked to egg aneuploidy by analyzing maternal exomes and shows kinesin gene variants contribute to aneuploidy and accelerated aging.

This study identifies a germline-specific DSN1 splice isoform essential for oocyte maturation and early embryonic development in mammals.

This study identifies the spatio-temporal roles of AURKA in mouse oocyte meiotic spindle formation using genetic and imaging approaches.

This study identifies CDK1/MAPK and AURKA/PLK1 pathways as converging on CPEB1 phosphorylation during mouse oocyte meiosis, showing CDK1 is critical for translation activation.

The paper uses ulc-WGS data from PGT-A to identify a genetic locus associated with maternal meiotic aneuploidy risk and validates its function in mouse oocytes.

The paper identifies 65 novel meiotic and fertility genes in Drosophila melanogaster through RNAi screening, showing their role in infertility and chromosomal nondisjunction.

The paper tracks CENP-A dynamics in mouse gametes and embryos, showing sex-specific differences in centromere maintenance and equalization during early development.

The paper identifies MLH1/3 variants in mice that cause reproductive defects, including subfertility and increased pregnancy loss due to meiotic abnormalities.