BiophysicsbioRxivPreprint
Perturbed cyclic strain results in a mechanically-induced, premature senescent phenotype in cardiac fibroblasts
Stephanie Ellyse Schneider, Adrienne K. Scott, Katie M. Gallagher…·Corey P. Neu
This study shows that perturbed mechanical stretch induces a premature senescent phenotype in cardiac fibroblasts through distinct pathways involving p53/p21 and p16.
DOI 10.1101/2025.03.16.643588