ImmunologybioRxiv
A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses
Samy Sid Ahmed, Liv Zimmermann, Andrea Imle…·Oliver T. Fackler
The paper identifies a tissue-intrinsic mechanism where the extracellular matrix restricts HIV-1 infectivity and enhances innate immune detection through conformational changes in viral Env and TLR recognition.
DOI 10.1038/s41467-026-72586-3