Targeting alpha-ketoglutarate starvation within the tumor-immune microenvironment rescues T cell effector function in cancer immunotherapy
Katarina Benejova, Kristina Travis, Deepti Mathur…·Martin Benej
This study shows that supplementing alpha-ketoglutarate (aKG) improves T cell function and immunotherapy effectiveness in NSCLC by reversing epigenetic changes associated with T cell exhaustion.