The Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Angiotensin II-mediated Functions in Mice
C.-H. Wu, C. Wu, D. A. Howatt, J. J. Moorleghen, L. A. Cassis, A. Daugherty, H. S. LU
This study shows that replacing amino acids 11 and 12 in mouse angiotensinogen with human counterparts does not affect renin cleavage or angiotensin II-mediated functions in mice.
bioRxiv · Dec 18, 2019Pathology