J. J. Moorleghen

This study examines how endogenous AngII levels change with exogenous AngII infusion and their impact on AAA and atherosclerosis in mice.

This study shows that inhibiting the AngII-AT1aR axis reduces aortic pathology in male Fbn1C1041G/+ mice, suggesting ligand-dependent AT1aR stimulation contributes to TAA progression.

This study introduces a para-spinal dorsal ultrasound approach to visualize descending aortic regions in mice, overcoming limitations of standard methods.

This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

This study shows hypercholesterolemia speeds up both the start and growth of angiotensin II-induced abdominal aortic aneurysms in mice.

This study shows that replacing amino acids 11 and 12 in mouse angiotensinogen with human counterparts does not affect renin cleavage or angiotensin II-mediated functions in mice.