Author

D. A. Howatt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 6 Physiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 8 Approach:experimental assay· 7 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Daugherty· 8 shared H. S. Lu· 8 shared J. J. Moorleghen· 7 shared H. Sawada· 6 shared M. K. Franklin· 4 shared J. Z. Chen· 2 shared M. Kukida· 2 shared Y. Katsumata· 2 shared

Activity by Year

2019-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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8 shared papersPathology

A. Daugherty

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8 papers

Recent·Most cited

Beta-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Young Mice

M. K. Franklin, H. Sawada, D. A. Howatt, N. Amioka, C.-L. Liang, N. Zhang, D. B. Graf, J. J. Moorleghen, Y. Katsumata, H. S. Lu, A. Daugherty

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

bioRxiv · Oct 22, 2023Pathology

Effects of Endogenous Angiotensin II on Abdominal Aortic Aneurysms and Atherosclerosis in Angiotensin II-infused Mice

M. Kukida, H. Sawada, S. Ohno-Urabe, D. A. Howatt, J. J. Moorleghen, M. Poglitsch, A. Daugherty, H. S. Lu

This study examines how endogenous AngII levels change with exogenous AngII infusion and their impact on AAA and atherosclerosis in mice.

bioRxiv · Nov 18, 2020Pathology

Inhibition of Angiotensin II Dependent AT1a Receptor Stimulation Attenuates Thoracic Aortic Pathology in Fibrillin-1C1041G/+ Mice

J. Z. Chen, H. Sawada, J. J. Moorleghen, M. K. Franklin, D. A. Howatt, M. B. Sheppard, A. E. Mullick, H. S. Lu, A. Daugherty

This study shows that inhibiting the AngII-AT1aR axis reduces aortic pathology in male Fbn1C1041G/+ mice, suggesting ligand-dependent AT1aR stimulation contributes to TAA progression.

bioRxiv · Jun 1, 2020Physiology

Bitter Melon (Momordica Charantia) Supplementation Has no Effect on Hypercholesterolemia and Atherosclerosis in Mice

S. Mohammadmoradi, D. A. Howatt, H. S. Lu, A. Daugherty, S. P. Saha

This study finds that bitter melon supplementation does not affect hypercholesterolemia or atherosclerosis in LDL receptor deficient mice.

bioRxiv · Apr 27, 2020Physiology

Ultrasound Monitoring of Descending Aortic Aneurysms and Dissections in Mice

H. Sawada, M. K. Franklin, J. J. Moorleghen, D. A. Howatt, M. Kukida, H. S. Lu, A. Daugherty

This study introduces a para-spinal dorsal ultrasound approach to visualize descending aortic regions in mice, overcoming limitations of standard methods.

bioRxiv · Apr 18, 2020Pathology

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies

H. Sawada, Y. Katsumata, H. Higashi, C. Zhang, Y. Li, S. Morgan, L. H. Lee, S. A. Singh, J. Z. Chen, D. A. Howatt, J. J. Moorleghen, M. K. Franklin, D. L. Rateri, Y. H. Shen, S. A. LeMaire, , A. Daugherty

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

bioRxiv · Feb 2, 2020Pathology

Hypercholesterolemia Accelerates Both the Initiation and Progression of Angiotensin II-induced Abdominal Aortic Aneurysms

J. Liu, H. Sawada, D. A. Howatt, J. J. Moorleghen, O. Vsevolozhskaya, A. Daugherty, H. S. Lu

This study shows hypercholesterolemia speeds up both the start and growth of angiotensin II-induced abdominal aortic aneurysms in mice.

bioRxiv · Jan 3, 2020 · PreprintPathology

The Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Angiotensin II-mediated Functions in Mice

C.-H. Wu, C. Wu, D. A. Howatt, J. J. Moorleghen, L. A. Cassis, A. Daugherty, H. S. LU

This study shows that replacing amino acids 11 and 12 in mouse angiotensinogen with human counterparts does not affect renin cleavage or angiotensin II-mediated functions in mice.

bioRxiv · Dec 18, 2019Pathology