Cancer BiologybioRxiv
Loss of tumor suppressor WWOX accelerates pancreatic cancerdevelopment through promotion of TGFβ/BMP2 signaling
H. Husanie, M. Abu-Remaileh, K. Maroun…·R. I. Aqeilan
This study shows that loss of WWOX promotes pancreatic cancer by enhancing TGFβ/BMP2 signaling, leading to increased cancer stemness and macrophage infiltration.
DOI 10.1038/s41419-022-05519-9