Author

E. Ma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2 Bioengineering· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

J. A. Doudna· 3 shared J. S. Chen· 2 shared X. Yang· 2 shared A. B. Brummer· 1 shared A. Diabate· 1 shared A. Kummer· 1 shared A. S. Probst· 1 shared A. Vander Ark· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 4 mutual co-author links

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3 shared papersBiochemistry

J. A. Doudna

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

L. Wan, H. Li, M. Liu, E. Ma, L. Huang, Y. Yang, Q. Li, Y. Fang, J. Li, B. Han, C. Zhang, L. Sun, X. Hou, H. Li, M. Sun, , H. Zhong

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

bioRxiv · Oct 10, 2022 · PreprintCell Biology

Improved Genome Editing by an Engineered CRISPR-Cas12a

E. Ma, K. Chen, H. Shi, E. C. Stahl, B. A. Adler, J. Liu, K. Zhou, J. Ye, J. A. Doudna

This paper improves CRISPR-Cas12a genome editing by combining rational engineering and directed evolution to enhance homology-directed repair efficiency.

bioRxiv · Sep 2, 2022Biochemistry

PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression

H. Guak, R. D. Sheldon, I. Beddows, A. Vander Ark, H. Shen, R. Jones, J. St. Pierre, E. Ma, C. M. Krawczyk

This study shows that PGC-1β promotes mitochondrial metabolism and suppresses inflammatory gene expression in dendritic cells.

bioRxiv · May 18, 2022Immunology

Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy

A. B. Brummer, X. Yang, E. Ma, M. Gutova, C. E. Brown, R. C. Rockne

This paper uses a mathematical model to show that dexamethasone destabilizes CAR T-cell efficacy in glioblastoma by altering coexistence dynamics and introducing critical thresholds.

bioRxiv · Oct 1, 2021Cancer Biology

Antimalarials in mosquitoes overcome Anopheles and Plasmodium resistance to malaria control strategies

D. G. Paton, A. S. Probst, E. Ma, K. L. Adams, W. R. Shaw, N. Singh, S. Bopp, S. K. Volkman, D. F. S. Hien, P. Pare, S. R. Yerbanga, A. Diabate, R. K. Dabire, T. Lefevre, D. Wirth, F. Catteruccia

This paper demonstrates that antimalarial drugs can block malaria transmission by targeting mosquitoes, remaining effective against resistant strains of both mosquitoes and parasites.

bioRxiv · Mar 12, 2021 · PreprintMicrobiology

Reimplementing Unirep in JAX

E. Ma, A. Kummer

The paper reimplements the UniRep model in JAX/NumPy to improve performance and provide a convenient API for specialized tasks.

bioRxiv · May 11, 2020 · PreprintBioengineering

DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis

N. Abbasi, T. Long, Y. Li, E. Ma, B. A. Yee, P. R. Patel, I. M. Sayed, N. Varki, S. Das, P. Ghosh, G. W. Yeo, W. J. M. Huang

This study identifies DDX5 as a regulator of tissue-specific oncogenic RNAs in intestinal tumorigenesis, showing its role in promoting colon and small intestine cancers.

bioRxiv · Mar 25, 2020Cancer Biology

CRISPR-Cas12a target binding unleashes single-stranded DNase activity

J. S. Chen, E. Ma, L. B. Harrington, X. Tian, J. A. Doudna

This study shows that CRISPR-Cas12a activates non-specific single-stranded DNA cleavage upon guide RNA-dependent DNA binding, distinguishing it from CRISPR-Cas9.

bioRxiv · Nov 29, 2017Biochemistry

A thermostable Cas9 with increased lifetime in human plasma

L. Harrington, D. Paez-Espino, J. S. Chen, E. Ma, B. T. Staahl, N. C. Kyrpides, J. A. Doudna

This paper describes a thermostable Cas9 variant from Geobacillus stearothermophilus that functions at higher temperatures and has increased stability in human plasma, expanding CRISPR-Cas9 applications.

bioRxiv · May 16, 2017Biochemistry