Author

L. C. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Alag· 1 shared A. Lakhani· 1 shared A. Shafer· 1 shared D. Nicolaou· 1 shared E. Salvestrini· 1 shared J. O. Park· 1 shared M. Khericha· 1 shared X. Chen· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioengineering

A. Alag

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1 paper

Recent·Most cited

Rational Tuning of CAR Tonic Signaling Yields Superior T-Cell Therapy for Cancer

X. Chen, M. Khericha, A. Lakhani, X. Meng, E. Salvestrini, L. C. Chen, A. Shafer, A. Alag, Y. Ding, D. Nicolaou, J. O. Park, Y. Y. Chen

This study shows that tuning CAR tonic signaling improves T-cell therapy efficacy by designing CARs with low but non-zero tonic signaling, enhancing anti-tumor activity in mouse models.

bioRxiv · Oct 1, 2020 · PreprintBioengineering