Author

L. Cisneros

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. C. Maley· 2 shared A. DeMichele· 1 shared A. Hall· 1 shared A. Khan· 1 shared A. M. Storniolo· 1 shared A. M. Thompson· 1 shared A. R. A. Anderson· 1 shared A. Sottoriva· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

C. C. Maley

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4 papers

Recent·Most cited

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

E. Lakatos, V. Gunasri, L. Zapata, J. Househam, T. Heide, N. Trahearn, O. Swinyard, L. Cisneros, C. Lynn, M. Mossner, C. Kimberley, I. Spiteri, G. D. Cresswell, G. Llibre-Palomar, M. Mitchison, , T. A. Graham

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

bioRxiv · Feb 12, 2024 · PreprintCancer Biology

Testing Adaptive Therapy Protocols using Gemcitabine and Capecitabine on a Mouse Model of Endocrine-Resistant Breast Cancer

S. SEYEDI, R. Teo, L. Foster, D. Saha, L. Mina, D. Northfelt, K. S. Anderson, D. Shibata, R. Gatenby, L. Cisneros, B. Troan, A. R. A. Anderson, C. C. Maley

This study tests adaptive therapy protocols using gemcitabine and capecitabine on a mouse model of endocrine-resistant breast cancer, finding improved survival with adaptive strategies over high-dose combination therapy.

bioRxiv · Sep 18, 2023 · PreprintCancer Biology

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

S. H. Strand, B. Rivero-Gutierrez, K. E. Houlahan, J. A. Seoane, L. M. King, T. Risom, L. A. Simpson, S. Vennam, A. Khan, L. Cisneros, T. Hardman, B. Harmon, F. Couch, K. Gallagher, M. Kilgore, , K Owzar

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

bioRxiv · Jun 16, 2021 · PreprintCancer Biology

Phylostratigraphic analysis of tumor and developmental transcriptomes reveals relationship between oncogenesis, phylogenesis and ontogenesis

J. Zhou, L. Cisneros, T. Knijnenburg, K. Trachana, P. Davies, S. Huang

The paper analyzes the evolutionary ages of cancer-related genes and finds they are enriched for pre-Metazoan genes, suggesting cancer reverts to an ancestral state.

bioRxiv · Oct 5, 2017Cancer Biology