K. Gallagher

Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.

The paper analyzes molecular differences in ductal carcinoma in situ (DCIS) by self-reported race and outcome groups, identifying variations in gene expression, tumor microenvironment, and copy number variations between Black and White women.

Structure of RADX and mechanism for regulation of RAD51 nucleofilaments

This paper investigates the structure and mechanism of RADX, a negative regulator of RAD51 nucleofilaments, showing it caps and restricts RAD51 filament growth to regulate replication fork reversal.

Learning to Adapt - Deep Reinforcement Learning in Treatment-Resistant Prostate Cancer

This paper applies deep reinforcement learning to adaptive drug scheduling in prostate cancer, showing it can extend time to progression by up to a quarter and outperform current protocols.

Two Interaction Surfaces between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair

The paper investigates two interaction surfaces between XPA and RPA in the preincision complex of nucleotide excision repair, showing their distinct roles in complex assembly and NER activity.

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

Who acquires infection from whom? Estimating herpesvirus transmission rates between wild rodent host groups

The paper estimates herpesvirus transmission rates between wild rodent host groups using population dynamic models applied to field data on naturally infected wood mice.

Protein complex stoichiometry and expression dynamics of transcription factors modulate stem cell division

The paper models SHR-SCR complex stoichiometry and regulation to explain differences in division timing between QC and CEI in Arabidopsis root stem cells.

Regulation of heterotopic ossification through local inflammatory monocytes in a mouse model of aberrant wound healing

This study identifies TGFβ1-producing monocytes/macrophages as drivers of heterotopic ossification in a mouse model and shows CD47 activation can reduce HO by modulating these cells.