Author

K. E. Houlahan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Khan· 3 shared C. Curtis· 3 shared P. C. Boutros· 2 shared A. DeMichele· 1 shared A. Gusev· 1 shared A. Hall· 1 shared A. J. Costello· 1 shared A. M. Storniolo· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

A. Khan

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5 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 15, 2023

Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity

K. E. Houlahan, A. Khan, N. F. Greenwald…·C. Curtis

This study shows germline variants influence somatic evolution in breast cancer by modulating immunoediting, affecting tumor subtype and metastatic potential.

DOI 10.1101/2023.03.15.532870

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintNov 16, 2022

Germline determinants of the prostate tumor genome

K. E. Houlahan, J. Yuan, T. Schwarz…·P. C. Boutros

The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.

DOI 10.1101/2022.11.16.516773

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 9, 2022

Deterministic evolution and stringent selection during pre-neoplasia

K. Karlsson, M. J. Przybilla, E. Kotler…·C. Curtis

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

DOI 10.1101/2022.04.09.487529

humanorganoid / primary culture

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJun 16, 2021

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

S. H. Strand, B. Rivero-Gutierrez, K. E. Houlahan…·K Owzar

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

DOI 10.1101/2021.06.16.448585

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivAug 20, 2018

Modeling the MYC-driven normal-to-tumour switch in breast cancer.

C. Lourenco, M. Kalkat, K. E. Houlahan…·L. Z. Penn

This study creates an in vivo model of MYC-driven breast cancer by combining PIK3CAH1047R mutation with deregulated MYC, showing a normal-to-tumour switch and dependence on MYC for tumor growth.

DOI 10.1242/dmm.038083

mouseexperimental assay

𝕏 PostBluesky