Author

L. Comai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 3 Cell Biology· 2 Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:plant (other)· 4 Assay:whole-genome sequencing· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 3 Organism:Arabidopsis· 2 Assay:DNA methylation· 2 Organism:mouse· 2

Frequent Co-Authors

I. M. Henry· 5 shared K. R. Amundson· 2 shared M. L. Nganga· 2 shared M. P. A. Marimuthu· 2 shared A. Britt· 1 shared A. Khan· 1 shared A. Phan· 1 shared A. Schnittger· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersPlant Biology

I. M. Henry

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Author profile →

8 papers

Recent·Most cited

A K-mer based Bulked Segregant Analysis approach to map seed traits in unphased heterozygous potato genomes

P. Sonsungsan, M. L. Nganga, M. Lieberman, K. Amundson, V. Steward, K. Plaimas, L. Comai, I. M. Henry

The paper introduces BSA-k-mer, a k-mer-based bulked segregant analysis method to identify genetic loci associated with seed traits in potato, finding novel loci for seed size and matching loci for seed spot.

bioRxiv · Oct 9, 2023Plant Biology

Differential mutation rates in plant meristematic layers

K. R. Amundson, M. P. A. Marimuthu, O. Nguyen, K. Sarika, I. J. DeMarco, A. Phan, I. M. Henry, L. Comai

The paper compares mutation rates in different layers of plant meristems and finds the L1 layer accumulates mutations 1.9 times faster than the L2.

bioRxiv · Sep 25, 2023Plant Biology

Differential outcomes of infection by wild-type SARS-CoV-2 and the B.1.617.2 and B.1.1.529 variants of concern in K18-hACE2 transgenic mice

Y. Yicheng He, J. E. Henley, P. Sell, L. Comai

This study compares the infectivity and inflammatory responses of SARS-CoV-2 wild-type, Delta, and Omicron variants in K18-hACE2 mice, finding differential viral RNA levels and inflammatory marker expression in lung, brain, and olfactory bulb tissues.

bioRxiv · Sep 8, 2023 · PreprintMicrobiology

GABA-receptors are a new druggable target for limiting disease severity, lung viral load, and death in SARS-CoV-2 infected mice

J. Tian, B. Dillion, J. Henley, L. Comai, D. Kaufman

This study shows that GABA-receptor agonists reduce disease severity, lung viral load, and death in SARS-CoV-2 infected mice.

bioRxiv · Jun 7, 2022Microbiology

The Arabidopsis Hop1 homolog ASY1 mediates cross-over assurance and interference

G. Pochon, I. M. Henry, C. Yang, N. C. Lory, N. Fernandez-Jimenez, F. Böwer, B. Hu, L. Carstens, H. T. Tsai, M. Pradillo, L. Comai, A. Schnittger

This study investigates the role of ASY1 in meiotic crossover (CO) assurance and interference in Arabidopsis, showing that reduced ASY1 activity leads to altered CO distribution and genomic instability.

bioRxiv · Mar 17, 2022Cell Biology

Biased removal and loading of centromeric histone H3 during reproduction underlies uniparental genome elimination

M. P. A. Marimuthu, R. Maruthachalam, R. Bondada, S. Kuppu, E.-H. Tan, A. Britt, S. S. W. Chan, L. Comai

The paper investigates how biased removal and loading of CENH3 during reproduction leads to uniparental genome elimination in Arabidopsis.

bioRxiv · Feb 24, 2021 · PreprintCell Biology

Rare instances of haploid inducer DNA in potato dihaploids and ploidy-dependent genome instability

K. R. Amundson, B. Ordonez, M. Santayana, M. L. Nganga, I. M. Henry, M. Bonierbale, A. Khan, E. H. Tan, L. Comai

The paper investigates the mechanism of dihaploid formation in potato by analyzing genome instability and the presence of haploid inducer DNA in dihaploids and hybrids.

bioRxiv · Nov 2, 2020Plant Biology

The persimmon genome reveals clues to the evolution of a lineage-specific sex determination system in plants

T. Akagi, K. Shirasawa, H. Nagasaki, H. Hirakawa, R. Tao, L. Comai, I. M. Henry

The paper investigates the evolution of dioecy in persimmon by analyzing genome duplication events and gene function, revealing how gene duplication and adaptation contributed to the development of a sex determination system.

bioRxiv · May 5, 2019Evolutionary Biology