Author

L. Dow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

M. Foronda· 2 shared A. Perez· 1 shared B. I. Leach· 1 shared B. J. Diaz· 1 shared C. Gilvary· 1 shared C. R. Vakoc· 1 shared C. S. Leslie· 1 shared E. M. Schatoff· 1 shared

Activity by Year

2019-2019 · peak 2/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

M. Foronda

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2 papers

Recent·Most cited

A machine learning approach predicts essential genes and pharmacological targets in cancer

C. Gilvary, N. Madhukar, K. Gayvert, M. Foronda, A. Perez, C. S. Leslie, L. Dow, G. Pandey, O. Elemento

This paper introduces ECLIPSE, a machine learning model that predicts essential genes and pharmacological targets in cancer by integrating genomic, cell line, and experimental features, showing better differentiation of approved cancer drugs from non-approved ones.

bioRxiv · Jul 4, 2019 · PreprintCancer Biology

Tankyrase inhibition sensitizes cells to CDK4 blockade

M. Foronda, Y. Tarumoto, E. M. Schatoff, B. I. Leach, B. J. Diaz, S. Goswami, M. Shusterman, C. R. Vakoc, L. Dow

This study identifies that combining TNKS inhibition with CDK4 loss drives G1 cell cycle arrest and senescence in epithelial cancers.

bioRxiv · Jun 21, 2019Cancer Biology