S. Goswami

Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockade

This study shows that inhibiting KDM6B in myeloid cells improves response to PD1 blockade in glioblastoma by enhancing anti-tumor immunity.

Histone Lactylation Drives CD8 T Cell Metabolism and Function

This study shows histone lactylation, specifically H3K18la and H3K9la, modulates CD8 T cell metabolism and function, impacting anti-tumor immunity.

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

Differential expression of miRNAs between Young-Onset and Late-Onset Indian colorectal carcinoma patients

The paper identifies differentially expressed miRNAs between young-onset and late-onset colorectal carcinoma patients and links them to epithelial-mesenchymal transition and tumor progression.

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

Role for DNA double strand end-resection activity of RecBCD in control of aberrant chromosomal replication initiation in Escherichia coli

The paper shows that reduced RecBCD end-resection activity in E. coli mutants rescues DnaA loss lethality under specific DNA damage conditions, suggesting a role in preventing aberrant replication.

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis.

This study shows that Glycyrrhiza glabra extract reduces inflammation and lung damage in hamsters infected with SARS-CoV-2 by lowering pro-inflammatory cytokines and NETosis.

S100A8 and S100A9, biomarkers of SARS-Cov-2-infected patients, suppress HIV replication in primary macrophages

This study shows that S100A8 and S100A9 subunits inhibit HIV replication in macrophages but not T cells, despite their role in SARS-CoV-2 infection.

Effect of prophylactic use of intra-nasal oil formulations in the hamster model of Covid-19

The paper evaluates two intra-nasal oil formulations in a hamster model of SARS-CoV-2 infection, finding that Anu oil reduces viral load, body weight loss, and lung pathology compared to the control.

Comparative in vitro antioxidant and antibacterial activities of leaf extract fractions of Crimson bottlebrush, Callistemon citrinus (Curtis.) Skeels

This study compares the antioxidant and antibacterial activities of different extract fractions from Callistemon citrinus leaves, finding the aqueous fraction has highest antioxidant activity while petroleum ether has highest antibacterial activity.

Comparative assessment of allelopathic herbicidal actions and total phenolics content of seven Indian medicinal plants

This study compares allelopathic effects and total phenolics content of seven Indian medicinal plants, finding Crinum asiaticum leaf extract shows the strongest inhibitory activity.

Comparative phytotoxicity and chironomid toxicity assessments of leaf successive extract fractions of Asiatic poison bulb, Crinum asiaticum L.

This study compares the phytotoxicity and chironomid toxicity of different extract fractions from Crinum asiaticum, finding the ethyl acetate fraction most toxic and the last aqueous fraction least toxic.

Effects of faecal inorganic contents in accurate measures of stress and nutrition hormone in large felines: implications for physiological assessments in free-ranging animals

This study examines how inorganic matter in feces affects stress and nutrition hormone measurements in tigers and lions, proposing corrections to improve accuracy.

Live imaging of breast tumors shows macrophage-dependent induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

The paper uses intravital imaging to show macrophage-induced cancer stem cells (CSCs) are enriched at TMEM doorways during metastasis, with CSCs comprising >60% of circulating tumor cells.

Effects of a combined enrichment intervention on the behavioural and physiological welfare of captive Asiatic lions (Panthera leo persica)

This study evaluates the impact of combined enrichment interventions on the welfare of captive Asiatic lions, finding improved behavioural diversity, reduced stress, and lower aberrant behaviours in treated animals.

Lineage reversion drives WNT independence in intestinal cancer

This study identifies lineage reversion as a mechanism enabling WNT-independent growth in intestinal cancer by integrating genetic alterations and extracellular signals.

Role of RBC membrane protein palmitoylation in regulation of molecular topology and susceptibility to Plasmodium falciparum invasion

The paper investigates how palmitoylation affects RBC membrane proteins and their role in Plasmodium falciparum invasion, finding that palmitoylation regulates receptor expression and susceptibility.

GO: A functional reporter system to identify and enrich base editing activity

The paper introduces a functional reporter system called GO to identify and enrich base editing activity in cells with high sensitivity and specificity.

An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants

The paper creates KRAS mutant mouse models to study how different oncogenic variants affect tumor development and therapy response in vivo.

Tankyrase inhibition sensitizes cells to CDK4 blockade

This study identifies that combining TNKS inhibition with CDK4 loss drives G1 cell cycle arrest and senescence in epithelial cancers.