Author

L. Frame

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:fluorescence / live-cell microscopy· 3 Research Focus:cell signaling & trafficking· 2 Approach:microscopy & imaging analysis· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

M. C. Leake· 3 shared A. Alevropoulos-Borrill· 1 shared A. Ejaz· 1 shared A. H. Squires· 1 shared A. L. Payne-Dwyer· 1 shared A. Noy· 1 shared A. Syeda· 1 shared B. Ambrose· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

M. C. Leake

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states

J. A. L. Howard, B. Ambrose, M. A. S. Abdelhamid, L. Frame, A. Alevropoulos-Borrill, A. Ejaz, L. Dresser, M. Dienerowitz, S. D. Quinn, A. H. Squires, A. Noy, T. D. Craggs, M. C. Leake

This study investigates the conformational transitions of Rep helicase using single-molecule techniques, revealing two intermediate states influenced by salt concentration.

bioRxiv · Jul 12, 2024Biophysics

RecA and RecB: probing complexes of DNA repair proteins with mitomycin C in live Escherichia coli with single-molecule sensitivity

A. L. Payne-Dwyer, A. Syeda, J. W. Shepherd, L. Frame, M. C. Leake

This study uses super-resolved fluorescence microscopy to analyze RecA and RecB dynamics in live E. coli under DNA damage, revealing their spatial organization and stoichiometry changes.

bioRxiv · Oct 4, 2021Biophysics

Investigating molecular crowding during cell division in budding yeast with FRET

S. Lecinski, J. Shepherd, L. Frame, I. Hayton, C. MacDonald, M. C. Leake

This study quantifies molecular crowding during budding yeast cell division using FRET sensors and microscopy, revealing crowding hotspots in daughter cells and potential mechanisms involving inherited organelles.

bioRxiv · Jul 29, 2021 · PreprintBiophysics