S. D. Quinn

This study identifies multiple intermediates in detergent-induced vesicle fusion using FRET and single-vesicle analysis, revealing a multi-step mechanism involving permeabilization, docking, hemi-fusion, and lipid mixing.

The paper investigates intracellular viscosity and molecular crowding using fluorescent nanobeads and molecular probes in vitro and in live yeast cells.

This study investigates how molecular crowding affects synthetic lipid vesicle morphology using smFRET and other techniques, finding that crowding induces compaction with varying reversibility depending on the crowder type.

This study investigates how Tween-20 interacts with lipid vesicles, revealing stepwise structural changes even below critical micellar concentration.

This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.

This study investigates the molecular dynamics of vesicle solubilization by SDS using advanced biophysical methods, revealing biphasic kinetics involving vesicle expansion and rapid lipid loss.

This paper demonstrates the use of ABEL traps for extended smFRET measurements of the molecular motor Rep, capturing conformational changes with sub-millisecond resolution.

This study uses svFRET to reveal the biphasic solubilization kinetics of vesicles by detergents, identifying an initial fast swelling step followed by slow lipid loss and micellization.