J. Shepherd

Correlating fluorescence microscopy, optical and magnetic tweezers to study single chiral biopolymers such as DNA

The paper introduces COMBI-Tweez, a tool combining optical and magnetic tweezers with fluorescence microscopy to study the structural dynamics of single chiral biopolymers like DNA under mechanical forces.

Crowding induced morphological changes in synthetic lipid vesicles determined using smFRET

This study investigates how molecular crowding affects synthetic lipid vesicle morphology using smFRET and other techniques, finding that crowding induces compaction with varying reversibility depending on the crowder type.

Investigating molecular crowding during cell division in budding yeast with FRET

This study quantifies molecular crowding during budding yeast cell division using FRET sensors and microscopy, revealing crowding hotspots in daughter cells and potential mechanisms involving inherited organelles.

Revealing intraosseous blood flow in the human tibia with ultrasound

This study uses ultrasound to quantify intraosseous blood flow direction and velocity in human tibia, revealing flow patterns consistent with known vascular organization.

Genome-wide Association Study of Pancreatic Fat: The Multiethnic Cohort Adiposity Phenotype Study

This study identifies two genetic variants associated with pancreatic fat content and suggests a potential link between pancreatic fat and type 2 diabetes.

Molecular crowding in single eukaryotic cells: using cell environment biosensing and single-molecule optical microscopy to probe dependence on extracellular ionic strength, local glucose conditions, and sensor copy number

This study uses FRET biosensing and microscopy to measure molecular crowding in yeast cells under varying glucose and ionic conditions, revealing uniform cytosolic crowding and sensor copy number dependencies.

Population genetics of the coral Acropora millepora: Towards a genomic predictor of bleaching

This study generates a genome assembly for Acropora millepora and identifies genetic predictors of bleaching using genome-wide association analysis.