Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification
L. Fruchard, A. Babosan, A. Carvalho, M. Lang, B. Li, M. Duchateau, Q. Giai Gianetto, M. Matondo, F. Bonhomme, I. Hatin, H. Arbes, C. Fabret, E. Corler, G. Sanchez, V. MArchand, , Z. Baharoglu
This study shows that Q34 modification in tRNA affects translational efficiency in Vibrio cholerae under aminoglycoside stress, leading to reprogramming of gene expression and antibiotic tolerance.
bioRxiv · Sep 26, 2022Microbiology