M. Matondo

Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis

This study shows that deleting Mtfp1 in hepatocytes increases mitochondrial respiration and protects against fatty liver disease.

The RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

The paper identifies CD9 and CD81 tetraspanins as key regulators of tunneling nanotubes through proteomic analysis and functional studies.

The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile

This study identifies CD1687 as a DNA-binding lipoprotein required for DCA-induced biofilm formation in C. difficile by promoting cell-matrix interactions through eDNA binding.

Rasputin/G3BP mediates o-nyong-nyong virus subversion of antiviral immunity in Anopheles coluzzii

This study shows that Rasputin in Anopheles mosquitoes is required for ONNV to inhibit antiviral immunity by co-opting its function to suppress immune pathways.

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

This study shows that Q34 modification in tRNA affects translational efficiency in Vibrio cholerae under aminoglycoside stress, leading to reprogramming of gene expression and antibiotic tolerance.

Hemisynthetic derivatives of the natural alkaloid trilobine are fast-acting antimalarial compounds with sustained activity in multi-drug resistant P. falciparum isolates

A balance between actin and Eps8/IRSp53 utilization in branched versus linear actin networks determines tunneling nanotube formation

This study identifies how the balance between branched and linear actin network formation, mediated by Eps8 and IRSp53, determines tunneling nanotube (TNT) formation.

Pneumococcus uses COMMD2 to alter host cellular immunity.

This study identifies COMMD2 as a bacterial factor that interacts with p65 and p62 to degrade p65, altering host cellular immunity during pneumococcal infection.

Mitochondrial fission process 1 (MTFP1) controls bioenergetic efficiency and prevents inflammatory cardiomyopathy and heart failure in mice

This study shows that MTFP1 is critical for cardiac function, as its loss in mice leads to dilated cardiomyopathy, heart failure, and death due to mitochondrial dysfunction and increased cell death.

Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming

This study shows that senescence promotes reprogramming through the SASP factor Amphiregulin, which enhances proliferation and MET via EGFR signaling, improving reprogramming efficiency.

Acetylation regulates the oligomerization state and activity of RNase J, the major ribonuclease of Helicobacter pylori

This study identifies acetylation of RNase J in H. pylori as a regulatory mechanism that modulates its oligomerization state and enzymatic activity.

NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes

This study shows that NAD kinase in Staphylococcus aureus supports virulence factor production and survival in host immune cells, reducing zebrafish mortality when inhibited.

Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

Ser/Thr kinase-dependent phosphorylation of the peptidoglycan hydrolase CwlA controls its export and modulates cell division in Clostridioides difficile

This study identifies CwlA as a substrate of the STK PrkC in C. difficile, showing that phosphorylation regulates its export and modulates cell division by controlling peptidoglycan hydrolysis.

Phosphorylation Dependent Assembly of a 14-3-3 Mediated Signaling Complex During Red Blood Cell Invasion by Plasmodium falciparum Merozoites

Revisiting Cryptococcus extracellular vesicles properties and their use as vaccine platforms

This paper characterizes the structural and compositional features of Cryptococcus extracellular vesicles and demonstrates their potential as vaccine candidates.

Characterization of extracellular vesicles produced by Aspergillus fumigatus protoplasts

This study characterizes extracellular vesicles from Aspergillus fumigatus protoplasts, showing they are produced across morphological stages and contain proteins and glycans related to metabolism and pathogenesis.

Proteomic Analysis Uncovers Measles Virus Protein C Interaction with p65/iASPP/p53 Protein Complex

The paper identifies p65/iASPP/p53 protein complex as a specific interaction partner of measles virus protein C, revealing its role in regulating cell death and innate immunity pathways.

Bacterial FtsZ induces mitochondrial fission in human cells

The paper shows that bacterial FtsZ can induce mitochondrial fission in human cells by localizing to fission sites and increasing fission levels.

The Flemmingsome reveals an ESCRT-to-membrane coupling required for completion of cytokinesis

The paper identifies a plasma membrane-to-ESCRT module essential for abscission, showing its role in cytokinesis, exosome formation, and HIV budding.

Cell-wall synthases contribute to bacterial cell-envelope integrity by actively repairing defects

The paper shows class-A penicillin-binding proteins (aPBPs), specifically PBP1b, repair cell-wall defects in E. coli to maintain integrity, independent of the Rod complex.

Transpeptidase PBP2 governs initial localization and activity of major cell-wall synthesis machinery in Escherichia coli

This study shows PBP2 initiates Rod complexes in E. coli by binding cell wall, not MreB or curvature, and limits Rod complex activity.

Listeria monocytogenes exploits the MICOS complex subunit Mic10 to promote mitochondrial fragmentation and cellular infection

This study identifies Mic10 as a host factor exploited by Listeria monocytogenes to induce mitochondrial fission and enhance cellular infection.

Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype

This paper demonstrates that Cryptococcus neoformans can enter a viable but non-culturable state under specific in vitro conditions, characterized by reduced metabolism and reactivation potential.

Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis

This study shows that TG2 activation during Chlamydia trachomatis infection enhances glucose uptake and hexosamine biosynthesis to support bacterial growth.