Author

L. Gamboa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1

Frequent Co-Authors

G. A. Kwong· 3 shared A. M. Harris· 2 shared A. Zamat· 2 shared F.-Y. Su· 2 shared H. Phuengkham· 2 shared S. N. Dahotre· 2 shared A. D. Silva Trenkle· 1 shared A. H. Zamat· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBioengineering

G. A. Kwong

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sensitizing solid tumors to CAR-mediated cytotoxicity using synthetic antigens

L. Gamboa, A. H. Zamat, D. Vanover, C. A. Thiveaud, H. E. Peck, H. Phuengkham, A. Sivakumar, A. M. Harris, S. N. Dahotre, F.-Y. Su, P. J. Santangelo, G. A. Kwong

This study develops synthetic antigens to enhance CAR T cell efficacy against solid tumors by reducing off-target effects and improving tumor targeting.

bioRxiv · Dec 11, 2021 · PreprintBioengineering

In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles

F.-Y. Su, Q. Zhao, S. N. Dahotre, L. Gamboa, S. S. Bawage, A. D. Silva Trenkle, A. Zamat, H. Phuengkham, R. Ahmed, P. Santangelo, G. A. Kwong

The paper develops a method to deliver mRNA to multiple virus-specific T cells using light-induced ligand exchange of MHC class I antigen-presenting nanoparticles, achieving ~50% transfection in vivo.

bioRxiv · Oct 14, 2021Bioengineering

Remote control of CAR T cell therapies by thermal targeting

I. C. Miller, L.-K. Sun, A. M. Harris, L. Gamboa, A. Zamat, G. A. Kwong

This paper develops a thermal targeting platform to remotely control CAR T cell therapies, showing significant enhancement in anti-tumor activity and survival in mouse models.

bioRxiv · Apr 26, 2020 · PreprintBioengineering

Mechanophenotyping of 3D Multicellular Clusters using Displacement Arrays of Rendered Tractions

S. E. Leggett, M. Patel, T. M. Valentin, L. Gamboa, A. S. Khoo, E. K. Williams, C. Franck, I. Y. Wong

The paper develops a method to measure multicellular tractions in 3D biomaterials using displacement arrays, revealing changes in traction patterns during epithelial-mesenchymal transition and drug perturbations.

bioRxiv · Oct 21, 2019Bioengineering

Heat-triggered remote control of CRISPR-dCas9 for tunable transcriptional modulation

L. Gamboa, E. V. Phung, H. Li, J. P. Meyers, G. Kwong

This paper introduces a method to remotely control CRISPR-dCas9 activity using heat, allowing dynamic transcriptional modulation in mammalian cells.

bioRxiv · Apr 12, 2019Bioengineering