Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics
A. Bonaud, L. Gargowitsch, S. Gilbert, E. Rajan, P. Canales-Herrerias, D. Stockholm, N. Rahman, M. Collins, D. L. Hill, A. Alloatti, N. Alouche, S. Balor, V. Soldan, D. Gillet, J. Barbier, , M. Espeli
This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.
bioRxiv · Jan 14, 2022 · PreprintImmunology