A KDELR-mediated ER retrieval system guides the signaling pathways of UPR and AMPK to maintain cellular homeostasis
M. Zhu, Z. Fang, Y. Wu, F. Dong, Y. Wang, F. Zheng, X. Ma, S. Ma, J. He, D. L. Hill, X. Liu, X. Yao, C. Fu
This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.
bioRxiv · Jun 14, 2023 · PreprintCell Biology