Author

S. Gilbert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 2 Ecology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Organism:human· 3 Organism:plant (other)· 2 Assay:proteomics· 2

Frequent Co-Authors

T. Lambe· 5 shared A. Flaxman· 2 shared A. Spencer· 2 shared E. Lam· 2 shared G. Saturday· 2 shared H. M. E. Duyvesteyn· 2 shared N. van Doremalen· 2 shared R. Fischer· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersMicrobiology

T. Lambe

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Structural and functional analysis of Pseudomonas aeruginosa PelA provides insight into the modification of the Pel exopolysaccharide

J. C. Van Loon, F. Le Mauff, M. Vargas, S. Gilbert, R. Pfoh, Z. A. Morrison, E. Razvi, M. Nitz, D. Sheppard, P. L. Howell

This study determines the structure of PelA and shows it modifies Pel through deacetylation and hydrolysis, with PelAB interaction enhancing deacetylation and guiding export.

bioRxiv · Jun 28, 2024Microbiology

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses

A. Flaxman, S. Sebastian, S. Appelberg, K. Cha, M. Ulaszewska, J. Purushotham, C. Gilbride, H. Sharpe, A. Spencer, S. Bibi, D. Wright, S. Dowall, L. Easterbrook, S. Findlay-Wilson, S. Gilbert, , T. Lambe

This paper develops a multi-pathogen vaccine targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses, showing strong immunogenicity and protective efficacy in animal models.

bioRxiv · Nov 3, 2023 · PreprintImmunology

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

P. Zhang, S. Gilbert, J. Radecke, T. Ni, L. Mendonca, Y. Zhu, A. Howe, P. M. Shah, Y. Sheng, A.-S. Krebs, H. M. E. Duyvesteyn, E. Allen, T. Lambe, C. Bissett, S. Morris, , D. I. Stuart

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

bioRxiv · May 22, 2023Microbiology

Optimization of molecular methods for detection and quantification of specific duckweed-bacteria interactions

K. Acosta, S. Sorrels, W. B. Chrisler, W. Huang, S. Gilbert, T. Brinkman, T. P. Michael, S. Lebeis, E. Lam

This study develops molecular methods to detect and quantify specific duckweed-bacteria interactions by optimizing protocols and creating strain-specific primers for accurate differentiation.

bioRxiv · Jan 4, 2023Ecology

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

A. Bonaud, L. Gargowitsch, S. Gilbert, E. Rajan, P. Canales-Herrerias, D. Stockholm, N. Rahman, M. Collins, D. L. Hill, A. Alloatti, N. Alouche, S. Balor, V. Soldan, D. Gillet, J. Barbier, , M. Espeli

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

bioRxiv · Jan 14, 2022 · PreprintImmunology

Antibody evasion by the Brazilian P.1 strain of SARS-CoV-2

W. - Dejnirattisai, D. - Zhou, P. - Supasa, C. - Liu, A. J. Mentzer, H. M. Ginn, Y. - Zhao, H. M. E. Duyvesteyn, A. Tuekprakhon, R. Nutalai, B. - Wang, G. C. Paesen, C. - Lopez-Camacho, J. - Slon-Campos, T. Walter, , Barne

This study compares antibody resistance of SARS-CoV-2 variants P.1, B.1.351, and B.1.1.7, finding P.1 is less resistant to antibodies despite similar ACE2 binding mutations.

bioRxiv · Mar 12, 2021Microbiology

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

R. Fischer, N. van Doremalen, D. Adney, C. Yinda, J. Port, M. Holbrook, J. Schulz, B. Williamson, T. Thomas, K. Barbian, S. Anzick, S. Ricklefs, B. Smith, D. Long, C. Martens, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

bioRxiv · Mar 11, 2021Microbiology

A single dose of ChAdOx1 MERS provides broad protective immunity against a variety of MERS-CoV strains

N. van Doremalen, E. Haddock, F. Feldmann, K. Meade-White, T. Bushmaker, R. Fischer, A. Okumura, P. Hanley, G. Saturday, N. Edwards, M. Clark, T. Lambe, S. Gilbert, V. Munster

A single dose of ChAdOx1 MERS vaccine protects rhesus macaques and mice against MERS-CoV infection and multiple strains.

bioRxiv · Apr 13, 2020 · PreprintMicrobiology

Genome and time-of-day transcriptome of Wolffia australiana link morphological extreme minimization with un-gated plant growth

T. P. Michael, E. Ernst, N. Hartwick, P. Chu, D. Bryant, S. Gilbert, S. Ortleb, E. L. Baggs, K. S. Sree, K. J. Appenroth, J. Fuchs, F. Jupe, J. P. Sandoval, K. V. Krasileva, L. Borisjuk, , E. Lam

This study analyzes the genome and time-of-day transcriptome of Wolffia australiana to link its extreme morphological minimization with reduced circadian regulation and continuous growth.

bioRxiv · Mar 31, 2020Plant Biology

Development and use of Lentiviral Vectors Pseudotyped with Influenza B Haemagglutinins: application to vaccine immunogenicity, mAb potency and sero-surveillance studies

F. Ferrara, G. Carnell, R. Kinsley, E. Bottcher-Friebertshauser, S. Pohlmann, S. Scott, S. Fereidouni, D. Corti, P. Kellam, S. Gilbert, N. J. Temperton

The paper develops influenza B haemagglutinin-pseudotyped lentiviral vectors as sensitive tools for detecting neutralizing and cross-reactive antibodies in vaccine and sero-surveillance studies.

bioRxiv · Dec 10, 2018 · PreprintMicrobiology