Cancer BiologybioRxiv
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
M. Pan, C. Wright, R. Chapple…·P. Geeleher
This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.
DOI 10.1038/s41467-021-26640-x