B. Freeman

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice

This study evaluates AB-free kava's effects on tobacco smoke-exposed mice, showing it mitigates health deficits with safety, suggesting potential for reducing tobacco-related harm.

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Latitudinal gradients in predation persist in urban environments

The paper tests if urbanization disrupts latitudinal gradients in seed predation across 14,000 km of latitude, finding that gradients persist despite habitat modification.

Genomic and Metabolic Hallmarks of SDH- and FH-Deficient Renal Cell Carcinomas

This study compares the genomic and metabolic features of SDH- and FH-deficient renal cell carcinomas, identifying distinct genetic and metabolic abnormalities.

An introduction to predictive distribution modelling for conservation to welcome novel perspectives

This paper introduces predictive distribution modeling for conservation, focusing on improving species distribution models to address challenges in spatial and temporal resolution and inform conservation strategies.

Efficacy of oseltamivir treatment in influenza virus infected obese mice

This study shows oseltamivir treatment does not improve viral clearance in obese mice and may increase viral genetic diversity and drug resistance.

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

Identification of an antiretroviral small molecule that appears to be a host-targeting inhibitor of HIV-1 assembly

This paper identifies two small molecules that inhibit HIV-1 assembly by targeting host factors involved in Gag assembly, showing efficacy against drug-resistant strains and lacking resistance mutations in Gag.

Sclerostin depletion induces inflammation in the bone marrow of mice

This study shows that sclerostin depletion in mice leads to myeloid-biased hematopoiesis and increased inflammation in the bone marrow.

The latitudinal gradient in rates of evolution for bird beaks, a species interaction trait

This study examines bird beak evolution rates across latitudes, finding similar beak size evolution but faster beak shape evolution in temperate zones, supporting the empty niches hypothesis.

Montane species track rising temperatures better in the tropics than in the temperate zone

The paper finds that tropical montane species track temperature increases more effectively than temperate species in two datasets, suggesting a latitudinal gradient in temperature tracking.

Validation of a SARS-CoV-2 spike ELISA for use in contact investigations and serosurveillance

This study optimizes and validates a SARS-CoV-2 spike ELISA for use in contact investigations and serosurveillance, demonstrating its specificity and sensitivity.

Adaptation and latitudinal gradients in species interactions: nest predation in birds

The paper shows that nest predation rates in birds do not vary with latitude when accounting for nesting period length, suggesting adaptation may equalize evolutionary rates across latitudes.

Mixed support for the idea that lower elevation animals are better competitors than their upper elevation relatives

The paper tests the Darwin-MacArthur hypothesis by analyzing competition between species along elevation gradients, finding that body size, not elevation, better predicts interspecific aggression.