Author

E. Stewart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Plant Biology· 2 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 7 Research Focus:cell type annotation· 6 Research Focus:differential expression· 4 Research Focus:drug response / drug discovery· 4 Assay:bulk RNA-seq· 3 Assay:proteomics· 3 Approach:statistical model· 3

Frequent Co-Authors

K. Blankenship· 3 shared M. A. Dyer· 3 shared X. Chen· 3 shared A. Bahrami· 2 shared A. G. Patel· 2 shared A. Pappo· 2 shared A. Shelat· 2 shared B. Gordon· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

K. Blankenship

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Germinal center BCR maturation in appendicitis reveals a role for antigen-specific adaptive immune responses during disease

E. Stewart, Z. Taghvaei, C. Leon, J. Shapiro, L. Zhu, L. Alpert, K. Turaga, R. Roy Chowdhury

This study identifies antigen-dependent B cell activation and microbial dysbiosis in appendicitis, linking immune and microbial factors to disease pathology.

bioRxiv · Jan 31, 2024 · PreprintImmunology

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma

S. G. Danielli, Y. Wei, M. A. Dyer, E. Stewart, M. Wachtel, B. W. Schaefer, A. G. Patel, D. M. Langenau

This study identifies therapy-resistant and tumor-acquired cell states in pediatric rhabdomyosarcoma using single-cell RNA sequencing.

bioRxiv · Oct 13, 2023Cancer Biology

Dominant CIZ1 fragments drive epigenetic instability and are expressed in early stage cancers

G. Turvey, E. Lopez de Alba, E. Stewart, L. Byrom, H. Cook, S. Sofi, A. Alati, J. Ainscough, A. S. Mason, A. A. Antson, D. Coverley

This study identifies that elevated CIZ1 anchor domain fragments in early stage cancers disrupt SMACs, leading to epigenetic instability by destabilizing PRC1-dependent histone modifications.

bioRxiv · Sep 22, 2023 · PreprintCell Biology

A genome-wide cytotoxicity screen of Cluster F1 mycobacteriophage Girr reveals novel inhibitors of Mycobacterium smegmatis growth

R. S. Pollenz, K. Barhnhill, A. Biggs, J. Bland, V. Carter, M. Chase, H. Clark, C. Coleman, M. Daffner, C. Deam, A. Finocchiaro, V. Franco, T. Fuller, J. G. Pinera, M. Horne, , D. Heller

This study screens phage genes to identify inhibitors of Mycobacterium smegmatis growth, finding 29 toxic genes, 12 of which are novel antimicrobial proteins.

bioRxiv · Aug 4, 2023 · PreprintMicrobiology

A bench-top dark-root device built with LEGO bricks enables a non-invasive plant root development analysis in soil conditions mirroring nature

G. Dermendjiev, M. Schnurer, E. Stewart, T. Naegele, G. Marino, D. Leister, A. Thuer, S. Plott, J. Jez, V. Ibl

The paper introduces a LEGO-based dark-root device for non-invasive root analysis in soil, showing root illumination affects proteome and phenotype in barley.

Frontiers in Plant Science · May 31, 2023Peer-reviewedPlant Biology

The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma

A. G. Patel, X. Chen, X. Huang, M. R. Clay, N. Komarova, M. J. Krasin, A. Pappo, H. Tillman, B. A. Orr, J. McEvoy, B. Gordon, K. Blankenship, C. Reilly, X. Zhou, J. L. Norrie, , M. A. Dyer

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.

bioRxiv · Jun 16, 2021Cancer Biology

Microtubules Promote the Non-cell Autonomy of MicroRNAs by Inhibiting their Cytoplasmic Loading into ARGONAUTE1 in Arabidopsis

L. Fan, C. Zhang, Y. Zhang, E. Stewart, J. Jez, K. Nakajima, X. Chen

The paper shows that microtubules inhibit miR165/6 loading into AGO1 in the cytoplasm, enabling its non-cell autonomous movement in Arabidopsis roots.

bioRxiv · May 26, 2021 · PreprintPlant Biology

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

M. Pan, C. Wright, R. Chapple, A. Zubair, M. Sandhu, J. Batchelder, J. Low, K. Blankenship, L. Wang, B. Gordon, P. Archer, S. W. Brady, S. Natarajan, M. Pozsgai, J. Schuetz, , P. Geeleher

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

bioRxiv · Feb 25, 2021Cancer Biology

Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress

J. Gartrell, M. Mellado-Lagarde, N. Martinez, M. Clay, A. Bahrami, N. Sahr, A. Sykes, K. Blankenship, L. Hoffmann, J. Xie, H. P. Cho, N. Twarog, M. Connelly, K.-K. Yan, J. Yu, , A. Shelat

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

bioRxiv · Nov 5, 2020 · PreprintCancer Biology

MYCN Amplification and ATRX Mutations are Incompatible in Neuroblastoma

M. Zeineldin, S. Federico, X. Chen, Y. Fan, B. Xu, E. Stewart, X. Zhou, J. Jeon, L. Griffiths, J. Easton, H. Mulder, D. Yergeau, Y. Liu, J. Wu, C. Van Ryn, , M. Dyer

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

bioRxiv · Jul 29, 2018Cancer Biology