C. Wright

A novel functional gene delivery platform based on a commensal human anellovirus demonstrates transduction in multiple tissue types

This paper develops a gene delivery vector based on a human anellovirus, demonstrating transduction in multiple tissues and durable in vivo function in mice.

Whole-genomes from the extinct Xerces Blue butterfly can help identify declining insect species

The paper sequenced genomes of extinct and historical Xerces Blue butterflies and their relatives to study population decline and identify genetic markers for threatened species.

BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates.

BashTheBug uses crowdsourced volunteers to accurately measure MICs of 13 antitubercular drugs from microdilution plates, showing median/mode of classifications is sufficient.

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

The same but different: setal arrays of anoles and geckos indicate alternative approaches to achieving similar adhesive effectiveness

This study compares setal morphology in Anolis lizards and geckos to show alternative structural strategies for achieving similar adhesive effectiveness.

Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture

This study develops a co-culture platform to study interactions between human colonic mucosal barriers and Faecalibacterium prausnitzii, showing anti-inflammatory effects and butyrate's role in modulating TLR3/4.

Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius

The paper identifies cis-regulatory regions controlled by cortex that determine scale color identity and pattern diversity in Heliconius butterflies through CRISPR perturbations and chromatin accessibility analysis.

Categorical Assignment of Pulmonary Embolism is a Simple and More Accurate Indicator of Right Ventricular Dysfunction and Short Team Mortality

This study compares risk stratification methods for acute pulmonary embolism, finding that categorizing patients by right ventricular dysfunction is more accurate than existing scoring systems.

Predictors of colony extinction vary by habitat type in social spiders

The study examines how environmental factors predict colony extinction in social spiders across different habitats, finding that ant attacks and fungal outbreaks are key drivers in deserts and savannas, respectively.