Cellular taxonomy of the preleukemic bone marrow niche of acute myeloid leukemia
C. Goda, R. Kulkarni, A. Rudich, M. Karunasiri, O. Balcioglu, Y. Al-Marrawi, E. Korn, S. Kanna, E. A. R. Garfinkle, B. Mundy-Bosse, B. Zhang, G. Marcucci, E. R. Mardis, R. Garzon, K. E. Miller, A. M. Dorrance
The paper identifies changes in the bone marrow microenvironment during preleukemic stages of AML, including an expanded CD55+ fibroblast population that supports preleukemic stem cells over normal HSCs.
bioRxiv · Sep 1, 2023Cancer Biology