N -acetylglucosamine supplementation fails to bypass the critical acetylation of glucosamine-6-phosphate required for Toxoplasma gondii replication and invasion
M. P. Alberione, V. Gonzalez-Ruiz, S. Rudaz…·J. Kloehn
This study shows that N-acetylglucosamine supplementation cannot restore UDP-GlcNAc levels or function in T. gondii when GNA1 is depleted, highlighting the critical role of GlcN6P acetylation in parasite replication and invasion.