BiochemistrybioRxivPreprint
Can we put Humpty Dumpty back together again? What does protein quantification mean in bottom-up proteomics?
D. L. Plubell, L. Käll, B.-J. Webb-Robertson…·M. J. MacCoss
The paper questions the assumption that all peptides from a protein coding gene represent the same protein quantity in bottom-up proteomics, highlighting the need for better methods to account for proteomic complexity.
DOI 10.1101/2021.01.25.428175