M. J. MacCoss

This study compares FAIMS and quadrupole gas-phase fractionation in peptide identification, finding that FAIMS improves results mainly by reducing co-isolation of precursor ions and chimeric spectra.

Mag-Net enriches membrane-bound particles from plasma to identify disease-specific proteins, discovering 204 proteins differentiating Alzheimer's disease dementia from controls.

The paper evaluates the Astral mass analyzer's performance in quantitative proteomics, showing it quantifies 5 times more peptides per unit time than existing Orbitrap mass spectrometers and detects over 5,000 plasma proteins.

This study identifies MBNL1 as a regulator of cardiac cell state transitions, showing it controls RNA stability to switch between regenerative and differentiated states.

This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.

This paper designs high-affinity protein binders for bioactive helical peptides using deep learning and generative models, achieving picomolar affinity without experimental optimization.

This study investigates how elamipretide affects age-related post-translational modifications in mouse heart proteins, finding that it reverses oxidative changes but not phosphorylation changes.

This study identifies novel SARS-CoV-2 epitopes using mass spectrometry and validates their immunogenicity by T cell recognition.

The paper introduces Magnum, an algorithm for identifying drug-protein adducts, and Limelight, a tool for analyzing and visualizing adduct data, validated with CYP3A4 examples.

This study identifies 46 putative actin filament interactors in Giardia lamblia, including proteins localized to the ventral disc, suggesting a role for GlActin in host attachment.

This study compares unit resolution and high-resolution mass spectrometry for parallel reaction monitoring, finding similar precision but better sensitivity with unit resolution for most peptides.

This paper introduces a staging system for Giardia encystation based on ESV morphology and molecular markers, validated through GlRac and Rab GTPase analysis.

The paper questions the assumption that all peptides from a protein coding gene represent the same protein quantity in bottom-up proteomics, highlighting the need for better methods to account for proteomic complexity.

This study identifies C1QBP as a negative regulator of Potato leafroll virus transmission by aphids using AP-MS and functional assays.

This study elucidates the role of the CM1 motif in Spc110p in facilitating γ-Tubulin Small Complex (γTuSC) assembly and γ-Tubulin Ring Complex (γTuRC) formation in yeast.

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

The paper demonstrates how to assess quantitative peptide measurements in proteomics using matrix-matched calibration curves and shows that more detected peptides do not guarantee more quantitatively measurable peptides.

This paper isolates and characterizes extracellular vesicles from C. elegans, showing they share key properties with mammalian EVs and enabling multi-omic analysis.

The paper introduces a workflow and software tool, EncyclopeDIA, to improve peptide quantification in DIA mass spectrometry by using chromatogram libraries calibrated to specific instruments.

The paper reports a phosphoproteomic analysis of yeast spindle pole bodies (SPBs) under two cell cycle conditions, identifying novel phosphorylation sites on γ-TuSC that regulate microtubule nucleation and spindle length.

This study shows the Ska complex directly strengthens kinetochore-microtubule attachments by forming a load-bearing connection with the Ndc80 complex and microtubule tips.

This study identifies time-specific interactors of the plant protein GIGANTEA using proteomics, revealing a new flowering regulator and non-rhythmic partners involved in proteostasis and metabolism.