Author

L. Kaczmarczyk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

G. Gerlitz· 2 shared D. Drago-Garcia· 1 shared D. Walsh· 1 shared E. Feldmesser· 1 shared E. Stuart· 1 shared F. Roncato· 1 shared I. Alexandrov· 1 shared J. C. Sabino· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

G. Gerlitz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Anti-prion drugs do not improve survival in knock-in models of inherited prion disease

D. Walsh, J. Rees, S. Mehra, M. Bourkas, L. Kaczmarczyk, E. Stuart, W. Jackson, J. Watts, S. Supattapone

This study tests anti-prion drugs on knock-in mouse models of inherited prion diseases and finds they do not improve survival or prevent prion accumulation.

bioRxiv · Sep 28, 2023 · PreprintPharmacology & Toxicology

Evolution of resistance to Irinotecan in cancer cells involves generation of topoisomerase-guided mutations in non-coding genome that reduce the chances of DNA breaks

S. Kumar, V. Gahramanov, S. Patel, J. Yaglom, L. Kaczmarczyk, I. Alexandrov, G. Gerlitz, M. Salmon-Divon, M. Y. Sherman

The paper investigates how cancer cells develop resistance to irinotecan by generating topoisomerase-guided mutations in non-coding regions, reducing DNA breaks and increasing drug resistance.

bioRxiv · Nov 26, 2021Cancer Biology

Nuclear lamin A/C promotes cancer cell survival and lung metastasis without restricting transendothelial migration

F. Roncato, O. Regev, S. W. Feigelson, S. K. Yadav, L. Kaczmarczyk, N. Levi, D. Drago-Garcia, S. Ovadia, M. Kizner, Y. Addadi, J. C. Sabino, Y. Ovadya, S. F. de Almeida, E. Feldmesser, G. Gerlitz, R. Alon

Cancers · May 14, 2021Peer-reviewedCancer Biology