S. Mehra

CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis

This study shows CREB promotes acinar-to-ductal reprogramming and pancreatic cancer progression in alcoholic pancreatitis models by enhancing fibrosis and tumor growth.

Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer

The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.

Transmission-blocking activity of artesunate, chloroquine and methylene blue on Plasmodium vivax gametocytes.

This study evaluates the transmission-blocking effects of artesunate, chloroquine, and methylene blue on Plasmodium vivax gametocytes, finding that only artesunate and methylene blue significantly reduce oocyst and sporozoite development.

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

Anti-prion drugs do not improve survival in knock-in models of inherited prion disease

This study tests anti-prion drugs on knock-in mouse models of inherited prion diseases and finds they do not improve survival or prevent prion accumulation.

Temporally variable drug profiles select for diverse adaptive pathways despite conservation of efflux-based resistance mechanism

This study shows that different drug exposure profiles lead to distinct mutation patterns in bacteria, despite using the same efflux-based resistance mechanism.

Neutrophil-Mediated Stromal-Tumor IL-6/STAT-3 Signaling Underlies the Association between Neutrophil-to-Lymphocyte Ratio Dynamics and Chemotherapy Response in Localized Pancreatic Cancer: A Hybrid Clinical-Preclinical Study

This study shows that neutrophil-to-lymphocyte ratio (NLR) dynamics predict chemotherapy response in pancreatic cancer and that targeting NLR improves chemosensitivity by modulating IL-6/STAT-3 signaling.

Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with KRAS-TP53 Co-Alteration in Pancreatic Cancer

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

This study uses longitudinal single-cell RNA sequencing in rhesus macaques to show that myeloid cell interferon responses correlate with SARS-CoV-2 clearance.

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancer

This paper shows that combining MEK and STAT3 inhibitors reprograms stromal inflammation and enhances immunotherapy response in pancreatic cancer.

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

The paper identifies the emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations in Papua New Guinea and suggests an independent origin with distinct genetic features.