J. Watts

Anti-prion drugs do not improve survival in knock-in models of inherited prion disease

This study tests anti-prion drugs on knock-in mouse models of inherited prion diseases and finds they do not improve survival or prevent prion accumulation.

Upregulated pexophagy limits the capacity of selective autophagy

The paper shows that increased pexophagy reduces the ability of selective autophagy to degrade mitochondria and protein aggregates, and this effect is observed in disease models.

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

The paper determines the structure of APOBEC3G bound to a DNA inhibitor, revealing the transition state geometry and providing insights for inhibitor design.

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.