Cancer BiologybioRxiv
Spatio-Genetic and Phenotypic Modelling Elucidates Resistance and Re-Sensitisation to Treatment in Heterogeneous Melanoma
A. Hodgkinson, L. Le Cam, D. Trucu, O. Radulescu
This paper models drug resistance and re-sensitisation in melanoma using mathematical frameworks, showing that spatio-genetic heterogeneity and treatment sequencing impact therapeutic outcomes.
DOI 10.1016/j.jtbi.2018.11.037