Author

L. Loo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Aggarwal· 3 shared C. L. Moreno· 3 shared G. G. Neely· 3 shared A. J. Cole· 2 shared A. O. Stella· 2 shared D. Hesselson· 2 shared F. Chung· 2 shared S. Turville· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. Aggarwal

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

A. Aggarwal, C. Fichter, V. Milogiannakis, T. Ison, M. Ruiz Silva, C. Esneau, N. Bartlett, L. Burrell, S. Patel, M. Churchill, T. Angelovich, R. Parry, J. D. Sng, G. G. Neely, C. L. Moreno, , S. G. Turville

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

bioRxiv · Sep 22, 2023 · PreprintMicrobiology

P-Selectin promotes SARS-CoV-2 interactions with platelets and the endothelium

C. L. Moreno, F. V. S. Castanheira, A. O. Stella, F. Chung, A. Aggarwal, A. J. Cole, L. Loo, A. Dupuy, Y. Kong, L. Hagimola, J. Fenwick, P. Coleman, M. Wilson, M. Bui-Marinos, D. Hesselson, , G. G. Neely

This study identifies P-selectin as a novel SARS-CoV-2 spike receptor that promotes viral interactions with platelets and endothelium, facilitating viral localization in airway capillaries.

bioRxiv · Feb 13, 2023Immunology

Anabolic Factors and Myokines Improve Differentiation of Human Embryonic Stem Cell Derived Skeletal Muscle Cells

T. Ruan, D. Harney, Y. C. Koay, L. Loo, M. Larance, L. Caron

This study enhances the differentiation of human embryonic stem cell-derived skeletal muscle cells using anabolic factors and myokines, improving fusion and muscle marker expression.

bioRxiv · Feb 8, 2022Cell Biology

Fibroblast-expressed LRRC15 suppresses SARS-CoV-2 infection and controls antiviral and antifibrotic transcriptional programs.

L. Loo, M. A. Waller, C. L. Moreno, A. J. Cole, A. O. Stella, O.-T. Pop, A.-K. Jochum, O. H. Ali, C. E. Denes, Z. Hamoudi, F. Chung, A. Aggarwal, J. K. K. Low, K. Patel, R. Siddique, , G. G. Neely

This study identifies LRRC15 as a host factor that suppresses SARS-CoV-2 infection and regulates antiviral and antifibrotic transcriptional programs in fibroblasts.

bioRxiv · Nov 9, 2021 · PreprintCell Biology