Y. Kong

Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression

This study shows that PLK1-mediated PDHA1 phosphorylation impairs mitochondrial function and promotes Cr(VI)-induced lung cancer progression by disrupting energy metabolism and apoptosis.

Reevaluating the Concept of Aging: Long-Term Stress Adaptation as a Key Factor in Yeast Aging

This study investigates how short-term and long-term stress affect yeast aging through transcriptomic and metabolomic analyses, finding that long-term stress activates aging-related genes that reduce lifespan.

Single-cell analysis characterizes PLK1 as a catalyst of an immunosuppressive tumor microenvironment in LUAD

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

Contact toxicity, antifeedant activity and oviposition preference of osthole against agricultural pests

This study evaluates the contact toxicity, antifeedant activity, and oviposition preference of osthole against three agricultural pests to assess its potential for pest control.

P-Selectin promotes SARS-CoV-2 interactions with platelets and the endothelium

This study identifies P-selectin as a novel SARS-CoV-2 spike receptor that promotes viral interactions with platelets and endothelium, facilitating viral localization in airway capillaries.

Thermal Stimulus Task fMRI in the Cervical Spinal Cord at 7 Tesla

This paper compares single-shot and multi-shot fMRI protocols for thermal stimulus task imaging in the cervical spinal cord at 7 T, finding differences in sensitivity and spatial localization of BOLD activation.

Increased TCR signaling in regulatory T cells is disengaged from TCR affinity

The paper compares TCR repertoires of regulatory and effector T cells in non-obese diabetic mice, showing similar reactivity but differing suppressive capacity linked to TCR affinity.

Comparative genomic analysis between Leonurus japonicus and Leonurus sibiricus

This study reports chromosome-level genome sequences of two Leonurus species, providing resources for studying bioactive molecules in medicinal plants.

Ultra-sensitive platelet proteome maps the O-glycosylation landscape and charts the response to thrombin dosage

This paper presents a high-sensitivity proteome analysis of human platelets, identifying O-glycosylation sites and showing that POFUT1 regulates MMRN1 secretion.

Inflammation Of The Retinal Pigment Epithelium Drives Early-Onset Photoreceptor Degeneration In Mertk-Associated Retinitis Pigmentosa

This study shows that RPE inflammation, not failed phagocytosis, drives early-onset photoreceptor degeneration in Mertk-deficient mice.

Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice

This study shows that Prdm13 signaling in the dorsomedial hypothalamus affects age-related sleep-wake changes in mice, and dietary restriction can mitigate these effects.

Epigenetic Changes in Saccharomyces cerevisiae Alters the Aromatic Profile in Alcoholic Fermentation

This study shows that benzoic acid and other dietary compounds alter epigenetic marks in Saccharomyces cerevisiae, changing its aromatic profile during fermentation.

Tissue-specific modifier alleles determine Mertk loss-of-function traits

This study shows that Mertk loss-of-function traits depend on tissue-specific modifier alleles, not just Mertk itself.

The Structural and Biochemical Basis for FER Receptor Kinase Early Signaling Initiation in Arabidopsis

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

Multiplexed imaging mass cytometry reveals distincttumor-immune microenvironments linked to immunotherapyresponses in melanoma

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

Size-scaling promotes senescence-like changes in proteome and organelle content

The paper investigates how cell size scaling affects proteome organization and organelle content, linking these changes to senescence-like features in human cells.

Characterization of glucosyltransferase and glucuronosyltransferase family members reveals how major flavone glycoside accumulate in the root of Scutellaria baicalensis

The paper identifies key glucosyltransferase and glucuronosyltransferase enzymes in Scutellaria baicalensis and shows how SbUGAT4 contributes to the high accumulation of baicalin in root tissues.

Detection of pigeon circoviruses in ticks of sheep and camels in Inner Mongolia, China

The paper detects pigeon circovirus in ticks collected from sheep and camels in Inner Mongolia using high-throughput sequencing and PCR, revealing its genomic sequence and phylogenetic classification.

Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Inner Mongolia, China

This study identifies new CCHFV strains in Inner Mongolia, China, showing genetic similarities to strains from Xinjiang and South Africa, suggesting long-term prevalence in the region.

Phytochrome contributes to blue-light-mediated stem elongation and associated shade-avoidance response in mature Arabidopsis plants

The paper investigates the role of phytochrome in blue-light-mediated stem elongation and shade-avoidance response in mature Arabidopsis plants using light treatments and phenotypic analysis.

IL-4-induced hysteresis in naive T cell activation

The paper shows that naive T cells exhibit transcriptional heterogeneity influenced by cytokines like IL-4, leading to hysteresis in immune responses.

The genome analysis of Tripterygium wilfordii reveals TwCYP712K1 and TwCYP712K2 responsible for oxidation of friedelin in celastrol biosynthesis pathway

This study identifies two CYP450 genes responsible for oxidizing friedelin to polpunonic acid in the celastrol biosynthesis pathway of Tripterygium wilfordii.

Blocking antibodies against SARS-CoV-2 RBD isolated from a phage display antibody library using a competitive biopanning strategy

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.

Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

Fully human single-domain antibodies against SARS-CoV-2

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

Chromatin-Bound PARP1 Correlates with Upregulation of Inflammatory Genes in Response to Long-Term Treatment with Veliparib

This study shows that long-term veliparib treatment leads to chromatin-bound PARP1 and upregulation of inflammatory genes in BRCA1 mutant cells, but not in BRCA1-complemented cells.

Dolosigranulum pigrum cooperation and competition in human nasal microbiota

The paper investigates D. pigrum's role in nasal microbiota by analyzing its interactions with other bacteria and genomic features, finding that it inhibits pathogens and relies on host and co-colonizing bacteria for nutrients.

Arabidopsis ERF4 and MYB52 Transcription Factors Play Antagonistic Roles in Regulating Homogalacturonan De-methylesterification in Seed Coat Mucilage