Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity
J. Prigann, D. Postmus, A. J. Pietrobon, E. Wyler, J. Jansen, L. Moeller, J. Fadejeva, T. Steijaert, C. Fischer, U. Koppe, B. Gunsenheimer-Bartmeyer, K. Meixenberger, S. Vitcetz, M. Sohn, L. Loyal, , C. GOFFINET
This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.
bioRxiv · May 4, 2020 · PreprintMicrobiology