C. Fischer

Assembling a true "Olympic Gel" from >16,000 combinatorial DNA rings

This paper creates a true Olympic gel from over 16,000 DNA rings, showing unique mechanical properties and swelling behavior due to entanglements.

Linking modulation of bio-molecular phase behaviour with collective interactions

This paper introduces a dominance analysis framework to determine the molecular mechanism of condensate modulation, demonstrating its application to G3BP1/RNA condensates disrupted by suramin.

Clarifying space use concepts in ecology: range vs. occurrence distributions

This paper distinguishes between range and occurrence distributions in ecology, showing that conflating them can lead to incorrect ecological inferences and conservation practices.

Cell Atlas at Single-Nuclei Resolution of the Adult Human Adrenal Gland and Adrenocortical Adenomas

This study creates a single-nuclei cell atlas of the adult human adrenal gland and adrenocortical adenomas, revealing progenitor cell populations and tumor heterogeneity.

Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

The paper shows that non-productive exposure of PBMCs to SARS-CoV-2 triggers JAK/STAT-dependent innate immune responses in monocytes, similar to those seen in mild COVID-19.

Tongue immune compartment analysis reveals spatial macrophage heterogeneity

This study identifies two distinct macrophage subsets in the murine tongue using single-cell RNA-sequencing and in situ immunophenotyping, revealing their spatial distribution and differential responses to systemic LPS.

Towards risk-based surveillance of African Swine Fever in Switzerland

This study develops a risk-based method to map ASF introduction risk into domestic pigs via wild boar in Switzerland using environmental and hunting data.

N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro

This study characterizes the reversible inhibition of SARS-CoV-2 and SARS-CoV Mpro by GC376, showing nanomolar Ki values and domain swapping in the drug-bound structures.

Human IFITM3 restricts Chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction

This study shows IFITM3 restricts CHIKV and MAYV infection and is counteracted by these viruses, with a variant showing similar antiviral activity to wild-type.

Ether lipid and sphingolipid expression patterns are G-protein coupled estrogen receptor 1-dependently altered in breast cancer cells

The paper identifies co-expression patterns of lipid classes in breast cancer cells, showing that ether lipids and sphingolipids are upregulated in G-protein coupled estrogen receptor 1-positive cells.

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

This paper shows that feline coronavirus drugs inhibit SARS-CoV-2 main protease and block virus replication in cell culture with low toxicity.

Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

The paper identifies DHODH as a target of GSK983 and shows that combining it with pyrimidine salvage inhibitors like CPU enhances antiviral efficacy against dengue virus.

Shark movements in the Revillagigedo Archipelago and connectivity with the Eastern Tropical Pacific

The paper tracks shark movements between islands in the Revillagigedo Archipelago and the Eastern Tropical Pacific to assess connectivity and migration patterns.

The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

Depletion of microbiome-derived molecules in the host using Clostridium genetics

This study develops a genetic method to disable Clostridium species and investigates the impact of microbiome-derived molecules on host IgA modulation.

N-hydroxy-pipecolic acid is a mobile signal that induces systemic disease resistance in Arabidopsis

This study identifies N-hydroxy-pipecolic acid as a mobile signal inducing systemic disease resistance in Arabidopsis by showing its role in SAR signal transduction and pathogen resistance.