Author

L. Marcho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:rat· 1

Frequent Co-Authors

J. M. Manouchehri· 2 shared M. A. Cherian· 2 shared B. Wang· 1 shared G. Urabe· 1 shared H. Shen· 1 shared J. Li· 1 shared K. C. Kent· 1 shared L.-W. Guo· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

J. M. Manouchehri

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3 papers

Recent·Most cited

The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer

J. M. Manouchehri, L. Marcho, M. A. Cherian

This study shows that inhibiting heparanase increases heparan sulfate levels, enhancing eATP and chemotherapy response in TNBC cells.

Breast Cancer Research · Nov 6, 2024Peer-reviewedCancer Biology

Sulfatase 2 Inhibition Sensitizes Triple-Negative Breast Cancer Cells to Chemotherapy Through Augmentation of Extracellular ATP

J. M. Manouchehri, L. Marcho, M. A. Cherian

This study shows that sulfatase 2 inhibition enhances chemotherapy effectiveness in TNBC by increasing extracellular ATP release and reducing cancer-initiating cells.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

A non-canonical role and regulations of polo-like kinase-4 in fibroblast cell-type transition

J. Li, G. Urabe, M. Zhang, Y. Huang, B. Wang, L. Marcho, H. Shen, K. C. Kent, L.-W. Guo

This study identifies a non-canonical role for PLK4 in fibroblast cell-type transition and shows its regulation by BRD4 and PDGFR pathways, suggesting PLK4 inhibition as a potential anti-fibrotic intervention.

bioRxiv · Mar 31, 2019 · PreprintCell Biology